2025年

Kobayashi K, Minegishi G, Kazuki K, Abe S, Sato M, Miyajima A, Hirabayashi M, Sakuma T, Yamamoto T, Kazuki Y. Double-humanized rats for CYP3A and PXR as an improved model for analyzing drug-drug interactions mediated by CYP3A4. AAPS J 27:123 (2025)

Nakajima M, Yamazaki H, Yoshinari Y, Kobayashi K, Ishii Y, Nakai D, Kamimura H, Kume T, Saito Y, Maeda K, Kusuhara H, Tamai I. Contribution of Japanese scientists to drug metabolism and disposition. Drug Metab Dispos, 53(5) 100071 (2025)

2024年

Minegishi G, Kobayashi Y, Fujikura M, Sano A, Kazuki Y, Kobayashi K. Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics. Pharmacol Res Perspect. 12:e1197 (2024)

Li Y, Kazuki Y, Drabison T, Kobayashi K, Fujita K, Xu Y, Jin Y, Ahmed E, Li J, Eisenmann ED, Baker SD, Cavaletti G, Sparreboom A, Hu S: Vincristine disposition and neurotoxicity are unchanged in humanized CYP3A5 mice. Drug Metab Dispos 52:80-85 (2024)

香月加奈子、小林カオル、平向洋介、香月康宏：染色体工学技術を用いたヒト化モデル動物作製と創薬研究への応用、アカデミア創薬の実践、善光龍哉・辻川和丈編、実験医学（増刊）（羊土社）、Vol.42-No.2, p192-199（322-329）（2024）

小林カオル：薬物代謝総論、薬物代謝酵素の阻害と誘導、生物薬剤学改訂第4版、pp. 101-103、pp. 115-124、谷川原祐介、井上勝央　編集、南江堂（2024）

2023年

Furutani Y, Hirano Y, Toguchi M, Higuchi S, Qin X-Y, Yanaka K, Sato-Shiozaki Y, Takahashi N, Sakai M, Kongpracha P, Suzuki T, Dohmae N, Kukimoto-Niino M, Shirouzu M, Nagamori S, Suzuki H, Kobayashi K, Masaki T, Koyama H, Sekiba K, Otsuka M, Koike K, Kohara M, Kojima S, Kakeya H, Matsuura T. A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor. Cell Death Discovery 9:467 (2023).

Kurosawa K, Nakano M, Yokoseki I, Nagaoka M, Takemoto S, Sakai Y, Kobayashi K, Kazuki Y, Fukami T, Nakajima M. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver. Biochemical Pharmacology 215:115733 (2023).

Kobayashi K, Minegishi G, Kuriyama N, Miyajima A, Abe S, Kazuki K, Kazuki Y. Metabolic disposition of triazolam and clobazam in humanized CYP3A mice with a double knockout background of mouse Cyp2c and Cyp3a genes. Drug Metab Dispos 51:174-182 (2023).

Natori N, Shibano Y, Hiroki A, Taguchi M, Miyajima A, Yoshizawa K, Kawano Y, Hanawa T.  Preparation and evaluation of hydrogel film containing tramadol for reduction of peripheral neuropathic pain. J Pharm Sci, 112:132-137 (2023).

小林カオル、香月康宏：ヒト化動物を用いた薬物代謝・動態研究への応用、実験動物ニュース 72(4) 167-172 (2023).

宮嶋 篤志: 【基礎薬学と臨床を結びつける薬学的解釈 アカデミック・ディテーリング】基礎薬学から考える医薬品情報 薬物動態学×アカデミック・ディテーリング、調剤と情報、29:2822-2825 (2023).

2022年

Kobayashi K, Deguchi T, Abe S, Kajitani N, Kazuki K, Takehara S, Nakamura K, Kurihara A, Oshimura M, Kazuki Y. Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes. Pharmacol Res Perspect 10: e01030 (2022).

Yamasaki Y, Moriwaki T, Ogata S, Ito S, Ohtsuki S, Minegishi G, Abe S, Ohta Y, Kazuki K, Kobayashi K, Kazuki Y. Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation. Pharmacogenetics and Genomics 32:288−292 (2022).

Cho N, Suemizu H, Kamimura H, Ohe T, Ito F, Akita H, Kobayashi K. Formation of Reactive Metabolite of Benzbromarone in Humanized-liver Mice. Drug Metab Pharmacokinet, 47:100467 (2022).

Katsumura S, Siddiqui N, Goldsmith MR, Cheah JH, Fujikawa T, Minegishi G, Yamagata A, Yabuki Y, Kobayashi K, Shirouzu M, Inagaki T, Huang THM, Musi N, Topisirovic I, Larsson O, Morita M. Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure. Cell Metabolism. 34:564-580 (2022).

宮嶋篤志：D. 高血糖・低血糖、がん支持医療テキストブック　サポーティブケアとサバイバーシップ、pp.232-236、日本がんサポーティブケア学会編、金原出版（2022）

2021年

Miyake T, Tsutsui H, Haraya K, Tachibana T, Morimoto K, Takehara S, Ayabe M, Kobayashi K, Kazuki Y. Quantitative prediction of P-glycoprotein-mediated drug–drug interactions and intestinal absorption using humanized mice. Br J Pharmacol. 178: 4335-4351 (2021).

Minegishi G, Kazuki Y, Nitta S, Miyajima A, Akita H, Kobayashi K. In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanized mice. Xenobiotica 51(7): 764-770 (2021).

Komoda M, Miyajima A, Koshino M, Akutsu S, Yamada M, Ozeki R, Makigami K. Case series of elderly patients with scabies topically applied with ivermectin via whole-body bathing. J Dematol, 48:559-563 (2021).

小林カオル：遺伝子改変動物を用いたヒト薬物代謝および毒性予測．明治薬科大学研究紀要、50、1-10 (2021).

2020年

Negishi M, Kobayashi K, Sakuma T, Sueyoshi T. Nuclear receptor phosphorylation in xenobiotic signal transduction. J Biol Chem, 295:15210-15225 (2020).

Ohta Y, Kazuki K, Abe A, Oshimura M, Kobayashi K, Kazuki Y. Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome. BMC Biotechnol, 20: 44 (2020).

Komoda M, Yamaguchi S, Takahashi K, Yanase K, Umezawa M, Miyajima A, Yoshimasu T, Sato E, Ozeki R, Ishii N. Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan. J Dermatol, 47:720-727 (2020).